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Single cell profiling of open chromatin status in human bone marrow mononuclear cells

Single cell profiling of open chromatin status in human bone marrow mononuclear cells from young and old donors

Prof. Bertie Göttgens and Dr. Nicola Wilson – Stem Cell Institute, University of Cambridge, UK

Contents:

Description
Results

Description

Cambridge University has existing plans to conduct single-cell CITE-Seq profiling of bone marrow CD34+ cells taken from samples from young and aged adults for the Human Cell Atlas project. Our pilot project aims to produce complementary single-cell ATAC-Seq data from cells taken from the same samples.

The bone marrow CD34+ cells will be taken from 4 healthy young male adults and 4 aged male adults in overall good health. The chromatin organization will be analyzed by using the single-cell ATAC-Seq technique to assess the epigenetic changes through the aging process.

Results

The project is currently under negotiations.