Nadace Aging Biology Foundation EU[1] and Aging Biology Foundation US[2], together with its co-investors, supports research aimed at advancing the biological foundations of healthy human aging by prioritizing the study of fundamental molecular mechanisms of epigenetic regulation, not necessarily in the aging context.
While the long-term goal of the Foundation is to better understand aging, our funding strategy reflects the view that meaningful progress in this area first requires elucidating core epigenetic mechanisms in well-controlled and interpretable systems.
Epigenetics, the study of how gene expression is regulated without changes to the DNA sequence, underlies a wide range of biological processes, including embryogenesis, cellular differentiation, tissue homeostasis, brain development and function, and ultimately aging. Despite major advances in the field, many fundamental principles of epigenetic regulation remain poorly understood.
ABF therefore currently focuses on hypothesis-driven projects that investigate fundamental epigenetic mechanisms, such as interactions among regulatory elements, transcription factors, chromatin remodelers, histone modifications, DNA methylation, nuclear lamina–associated regulation, and related processes. Of particular interest is the direction of site-specific de novo epigenetic modifications. The Foundation prioritizes research in specific contexts of development or differentiation, particularly in mammalian systems, including mouse models.
Collaborative grants with academic laboratories are welcome.
We invite applicants to submit an initial 1–2 page concept note outlining the research idea, key methods, estimated timeline, and project budget to grants@agingbiology.org. Selected applicants will be invited to submit a full proposal.
Who can apply:
A necessary condition is access to the infrastructure required for the successful implementation of the project.
The grant amount is a subject of the proposed scope of work and can vary from $50.000 up to $4.000.000
The grant period: from 6 months up to 5 years.
How to apply:
Please, send us your grant application at grants@agingbiology.org
You are welcome to submit your grant proposal at any time; there are no deadlines. We also don’t have any specific requirements for the length or formatting of the grant proposal.
The grant application should consist of a research proposal, and commitment letters from the primary applicant’s organization and from each collaborator’s or subcontractor’s organization acknowledging and accepting the Foundation Grant Application and Indirect Cost Guidance
After approval:
If the grant is approved, donees also have the opportunity to receive free consultation support in computational methods from our collaborators: JetBrains Research BioLabs
The grant proposal should include:
[1] Nadace Aging Biology Foundation EU, a non-profit legal entity incorporated under the laws of the Czech Republic, with its registered address at Na hřebenech II 1718/8, 140 00 Praha 4 – Nusle, Czech Republic, ID: 108 65 951, registered in the Foundation Register, Section N, Insert 1945.
[2] Aging Biology Foundation, Inc., a non-profit corporation organized and existing under the laws of Massachusetts (USA), having its registered address at 221 Crescent Street, Suite 401 Waltham, MA 02453, USA, ID: 001179742.